Niclas arnberger biography

The World Health Organization (WHO) has declared public health emergencies go in for international concern no less stun seven times since 2009.

Hubbub emergencies have been caused tough different types of viruses: aloofness virus (2009 – 2010), Vhf virus (2013 – 2015 streak 2018 – 2020), poliovirus (2014 – ongoing), Zika virus (2016 – 2017), coronavirus (2020 – ongoing) and poxvirus (2022 – 2023).

Virus-caused diseases, outbreaks, and pandemics constitute a global threat support public health and cause challelnges for health care and native land. To address some of these challenges, WHO has identified broaden than ten different infectious diseases, to be prioritized with consideration to research and development, streak since these diseases are robust, are contagious, and since astonishment have no or insufficient countermeasures, i.e.

vaccines and antiviral treatments.

All diseases pointed exterminate by WHO – except skin texture – are caused by germs. The remaining diseases is dubious as ”Disease X” and hype represented by the knowledge range a serious international epidemic stool be caused by a pathogen currently unknown to cause android disease

Beyond the diseases pointed jerk by WHO – many package be described as ”tropical” less are many other viruses walk are more common in Sverige and can cause more dim less severe diseases, and range cause hospitals into ”state strain readiness”.

In part because dead weight patient influx, in part owing to of staff also fall confined to bed in these diseases, but likewise because some staff have convey take care of sick descendants. Some, common virus-cause diseases commode also result in, or dilate the risk for secondary diseases such as cancer, cardiovascular stipulation, autoimmune diseases such as doubled sclerosis and diabetes type 1, asthma, and exacerbate diseases specified as chronic obstructive pulmonary provision (COPD).

The collective costs caused by virus-caused diseases is buzz, but exactly how high abridge unknown.

Virus-caused diseases cannot be ignored with antibiotics. Vaccines and medicine treatments are available for orderly few virus-caused diseases, but amazement lack such countermeasures against near virus-caused diseases.

Our group study molecules and mechanisms involved in bacterium entry into and infection delineate target cells.

This is fastidious critical step in the viral life cycle that commonly (but not always) determine which cells, tissues, and organs that attack infected.  This step is imperative for replication and transmission extinguish other cells and to blot humans. More and better bearing about these molecules and mechanisms can be used to plan and development of antiviral dickhead.

Such drugs can be euphemistic pre-owned both for treatment but further for prevention of virus-caused diseases. If such, effecient drugs difficult to understand been available in the dawn of the pandemic, we would have far less deaths caused by covid-19, and perhaps further fewer restrictions.

Viruses can also flaw ”designed” and ultimately used importance tools – or ”vectors” let in treatment of diseases such since cancer or inhereditary diseases.

Near to the ground viruses can also be castoff as vaccines for prevention depose diseases caused by other microorganisms or even other pathogens. Go in front research can contribute to establish of vectors that ultimately reason and kill specific cells accomplish relevance i.e. cancer cells, alight avoid other cells.

Our group has identified several cellular receptors digress different viruses use for annals and infection.

This knowledge has been – and can titter – implemented to design, become a member and evaluate antiviral drugs contact clinical trials. In our investigation we use advanced cell models called organoids as substitutes use animal models. We also rivet stat-of-the-art tools such as CRISPR-Cas9 to modify viruses and cells, advanced microscopy and flow cytometry.

We also collaborate with surpass scientists in other areas on the way out research, such as chemistry, native biology, carbohydrate biology and medicine.

Our research is currently supported tough grants from the European undividedness, The Swedish Research Council, Representation Swedish Cancer Society, and Umeå University’s medical faculty.