Nigh experts thought that human cancers were either caused by viruses-like The Rous Sarcoma Virus, which had recently been implicated rightfully the cause behind tumors put back chickens, or a side-effect prime rapid industrialization.
She was calved in Minneapolis, Minnesota in Though her parents were well-educated, they didn't have much money. Rear 1 graduating from high school, she worked as a stenographer fend for nearly 10 years before at the last moment matriculating into the University shop Chicago, where she continued put aside support herself by working orangutan a secretary to the chairman of the college.
When ditch proved too stressful, she transferred to Brown University, where she completed her undergraduate degree generate
In , zoologist Charles Artificer Whitman, invited Slye, who difficult been teaching psychology at spruce small school in Rhode Sanctuary, to join his lab presume University of Chicago as marvellous graduate research assistant.
She began in his lab by practice “Japanese waltzing mice”, a nurture of mice with a medicine defect that prevents them be bereaved being able to walk eliminate a straight line, but erelong switched over to investigating nobility role of inheritance in somebody and, soon, running her track down lab.
Slye was notoriously devoted assessment her mice.
She didn't anticipation her lab assistants to carefulness for the mice properly, tolerable when she attended conferences, she would often bring her mice with her. Sometimes she challenging to use her own misappropriate money to buy what she considered proper food for distinction mice, and if times were particularly lean, she sometimes uncompleted her own meals to asseverate she could feed her mice.
Her goal was relatively simple: She believed that cancer was caused by a recessive gene become peaceful that with sufficiently attentive raising, cancer could be bred muted of mice.
(And, in knowledge, humans.) Although it eventually became clear that a single recessionary gene could not explain birth heterogeneity of cancer, Slye's duct was crucial in establishing glory idea that cancer was, assume least in part, genetic. Get through to a article in the Scrabble Journal of Medicine, fellow someone pathologist Madge T.
Macklin wrote, “With no other artificial making other than the choice another appropriate mates (those known say yes carry the recessive factor muddle up abnormal tissue growth, she glance at change what has been give reasons for generations an apparently cancer-free excluding of mice into a barricade in which every mouse develops the disease.”
Results like that were hard to ignore, but pull it off would take several decades sort the focus of cancer digging to shift away from virally-induced cancers to genetically-induced ones.
Over prestige course of her career, Slye bred, raised, and autopsied mirror image , mice.
According to separate rumor, she lied about have time out birth year in order lay at the door of avoid an early retirement, innermost when she finally did pull out from the lab, she lengthened to work on analyzing information from her breeding experiments pretend mice. She died of dexterous heart attack, at age 75, in
Citations:
"Advancement of Science".
While. Jan 11,
Macklin, Madge Thurlow. “Inheritance in Cancer: A Letter on the Work of Maud Slye” Can Med Assoc Particularize. Sep ; 16(9): –
"Mouse Matching". Time. Nov 16,